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Non-coding RNAs in Prostate Cancer: From Discovery to Clinical Applications.

In English

Författare

Redaktör

  • Dagmar Wilhelm
  • Pascal Bernard

Summary, in English

Prostate cancer is a heterogeneous disease for which the molecular mechanisms are still not fully elucidated. Prostate cancer research has traditionally focused on genomic and epigenetic alterations affecting the proteome, but over the last decade non-coding RNAs, especially microRNAs, have been recognized to play a key role in prostate cancer progression. A considerable number of individual microRNAs have been found to be deregulated in prostate cancer and their biological significance elucidated in functional studies. This review will delineate the current advances regarding the involvement of microRNAs and their targets in prostate cancer biology as well as their potential usage in the clinical management of the disease. The main focus will be on microRNAs contributing to initiation and progression of prostate cancer, including androgen signalling, cellular plasticity, stem cells biology and metastatic processes. To conclude, implications on potential future microRNA-based therapeutics based on the recent advances regarding the interplay between microRNAs and their targets are discussed.

Avdelning/ar

Publiceringsår

2016

Språk

Engelska

Sidor

155-170

Publikation/Tidskrift/Serie

Advances in Experimental Medicine and Biology

Volym

886

Dokumenttyp

Del av eller Kapitel i bok

Ämne

  • Urology and Nephrology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0065-2598
  • ISBN: 978-94-017-7417-8
  • ISBN: 978-94-017-7415-4