Efficient removal of platelets from peripheral blood progenitor cell products using a novel micro-chip based acoustophoretic platform.

Summary, in English

Excessive collection of platelets is an unwanted side effect in current centrifugation-based peripheral blood progenitor cell (PBPC) apheresis. We investigated a novel microchip-based acoustophoresis technique, utilizing ultrasonic standing wave forces for the removal of platelets from PBPC products. By applying an acoustic standing wave field onto a continuously flowing cell suspension in a micro channel, cells can be separated from the surrounding media depending on their physical properties.

• Författare: Josefina Dykes; Andreas Lenshof; Ingbritt Åstrand-Grundström; Thomas Laurell; Stefan Scheding
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin; Avdelningen för Biomedicinsk teknik; Stamcellscentrum (SCC); Benmärgsstamceller och cellulära terapier; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2011
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 6
• Issue: 8
• Fulltext: - 1 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/21857996?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0023074
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Cell and Molecular Biology; Hematology
• Status: Published
• Forskningsgrupp: Bone marrow stem cells and cellular therapies
• ISBN/ISSN/Övrigt: ISSN: 1932-6203