HCV-RNA levels increase during pregnancy in women with chronic hepatitis C
Författare
Summary, in English
Alanine aminotransferase (ALT) levels decline during pregnancy in women chronically infected with hepatitis C virus (HCV). In order to understand further the underlying mechanisms, we prospectively followed 10 chronically infected women before, during and after pregnancy. ALT levels were analysed together with quantification of serum HCV-RNA using the branched DNA technology. As anticipated, the ALT levels significantly declined late in pregnancy and increased again after delivery. HCV-RNA levels, conversely, significantly increased late in pregnancy and returned to baseline levels 1 y after delivery. These findings suggest the importance of immune mediated mechanisms in controlling the viral replication and contributing to the liver injury in chronic hepatitis C.
Avdelning/ar
Publiceringsår
1998
Språk
Engelska
Sidor
111-113
Publikation/Tidskrift/Serie
Scandinavian Journal of Infectious Diseases
Volym
30
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Informa Healthcare
Ämne
- Infectious Medicine
Status
Published
Forskningsgrupp
- Clinical Microbiology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1651-1980