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Altered behavioural responses and functional recovery in rats following sciatic nerve compression and early vs late decompression

Författare

Summary, in English

Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition. Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after decompression. The sciatic nerve of the rats was experimentally compressed for 3 or 28 days, whereafter surgical release, i.e. decompression, of the nerve was performed and the rats were examined up to ∼9 weeks. Results: An altered behaviour was found in response to compression injury, which is mitigated after early decompression treatment. Conclusions: These findings indicate that early intervention during severe compression injuries is of great importance for recovery and restoration of nerve function and, thus, should have an impact on clinical routines regarding treatment of compression injuries.

Publiceringsår

2016-11

Språk

Engelska

Sidor

321-330

Publikation/Tidskrift/Serie

Journal of Plastic Surgery and Hand Surgery

Volym

50

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Neurosciences

Nyckelord

  • allodynia
  • decompression
  • hyperalgesia
  • nerve compression
  • Nerve injury
  • pain
  • sensorimotor behaviour

Status

Published

Forskningsgrupp

  • Neuronano Research Center (NRC)
  • Hand Surgery, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 2000-656X