Long-term lead elimination from plasma and whole blood after poisoning.
Författare
Summary, in English
OBJECTIVE:
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
311-316
Publikation/Tidskrift/Serie
International Archives of Occupational and Environmental Health
Volym
85
Fulltext
- Available as PDF - 233 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Environmental Health and Occupational Health
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1432-1246