PNA-programmed self-assembies for responsive systems
Professor of Organic and Bio-organic Chemistry, University of Geneva, Switzerland
Title: “PNA-programmed self-assembies for responsive systems”
Place: Hall C, Chemical Center, Naturvetarvägen 14
Chemical biology, Self-assembly, cooperative interactions, PNA, DNA
The programmable nature of nucleic acid hybridization has inspired a number of applications beyond their natural function in heredity. Peptide Nucleic Acids (PNA) are endowed with attractive properties for this endeavor as they are more robust and form more stable duplex than their natural counter parts. Several applications from our laboratory to encode and program self-assemblies of small molecules, template chemical reactions or display multimeric ligands will be presented.
1. PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions, S. Barluenga, N. Winssinger, Acc. Chem. Res. 2015, 48, 1319-1331
2. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules, Chem. Sci., 2015, 6, 739-744.
3. Identification of Covalent Bromodomain Binders from DNA Display of Small Molecules, Angew. Chem. Int. Ed. 2015, 54, 6057-61.
4. Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization, T. Machida, S. Dutt, N. Winssinger,Angew. Chem. Int. Ed. 2016, 55, 8595-8.
5. Nucleic-acid templated chemical reaction in a live vertebrate, L. Holtzer, I. Oleinich, M. Anzola, K. K. Sadhu, M., E. Lindberg, Gonzalez-Gaitan, N. Winssinger, ACS Central Science,2016,2, 394-400.
6. Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity, D. Chang, E. Lindberg, N. Winssinger, J. Am. Chem. Soc. 2017, 139, 1444-1447.
7. Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells, T. Machida, A. Novoa, E. Gillon, S. Zheng, J. Claudinon, T. Eierhoff, A. Imberty, W. Römer, N. Winssinger Angew. Chem. Int. Ed. 2017, 56, 6762-6766.
8. Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection, J. Sayers, R.J. Payne, N. Winssinger, Chem. Sci.2018, 9, 896-903.
9. Luciferase-induced photoreductive uncaging of small-molecule effectors, E. Lindberg, S. Angerani, M. Anzola, N. Winssinger, Nature Commun. 2018, 9, 3539
The lecture is open to the public and will be held in english. After the lecture there will be an informal reception at the Centre for Analysis and Synthesis (CAS), where you can meet the lecturer and the other attendants. Pea soup with punsch and pancakes (50 SEK) will be served, as well as other refreshments.
Register for the reception no later than Wednesday 29/5 by sending an e-mail to niklas.warlin 'at' chem.lu.se.
The lecture is open to the public and will be in English. Entrance E at Naturvetarvägen 14 will be held open a short time before the lecture for visitors without access-cards.