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A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2.

In English

Författare

Summary, in English

The variable regions of allergen-specific IgE, the isotype mediating allergic responses, are poorly defined to date. In this study we define the character of human antibody binding sites recognizing Phl p 2, a major allergen from timothy grass pollen. Independently raised specificities developed by phage display technology tended to have common sequence motifs (idiotypes), such as IGHV4-31 germline gene origin and heavy chain complementarity-determining region (CDR) 3 length and sequence. They also combined with highly related light chain sequences. Such heavy chain variable domain-encoding transcripts have also been found in the IgE-encoding transcriptome of yet other grass pollen allergic subjects. Altogether these data argue that a common idiotype is used to establish specific antibodies with a potential to mediate allergic responses to Phl p 2. Such a restriction may contribute to the limited molecular diversity observed in some IgE populations.

Publiceringsår

2008

Språk

Engelska

Sidor

2715-2720

Publikation/Tidskrift/Serie

Molecular Immunology

Volym

45

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

Pergamon Press Ltd.

Ämne

  • Immunology in the medical area

Status

Published

Projekt

  • Human IgE repertoires and an anti-allergome resource

ISBN/ISSN/Övrigt

  • ISSN: 1872-9142