Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro
Författare
Summary, in English
We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
7426-7433
Publikation/Tidskrift/Serie
Bioorganic & Medicinal Chemistry
Volym
15
Issue
23
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Zoology
Nyckelord
- Modified nucleoside
- Adenosine
- Uridine
- Polyamine derivatives
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0968-0896