Attovial-based antibody nanoarrays.

Summary, in English

Antibody array-based technology is a powerful emerging tool in proteomics, but to enable global proteome analysis, antibody array layouts with even higher density has to be developed. To this end, we have further developed the first generation of a nanoarray platform, based on attoliter sized vials, attovials, which we have characterized and used for the detection of complement factor C1q in human serum samples. Finally, we demonstrated proof-of-concept for individual functionalisation of the attovials with a recombinant antibody.

• Författare: Peter Ellmark; Sara Ghatnekar-Nilsson; André Meister; Harry Heinzelmann; Lars Montelius; Christer Wingren; Carl Borrebaeck
• Avdelning/ar: Institutionen för immunteknologi; Fasta tillståndets fysik
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 5406-5413
• Publikation/Tidskrift/Serie: Proteomics
• Volym: 9
• Issue: 24
• Länkar: http://dx.doi.org/10.1002/pmic.200800962
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Immunology in the medical area; Condensed Matter Physics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1615-9861