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Cortical thickness changes following spatial navigation training in adulthood and aging

In English

Författare

  • Elisabeth Wenger
  • Sabine Schaefer
  • Hannes Noack
  • Simone Kuehn
  • Johan Mårtensson
  • Hans-Jochen Heinze
  • Emrah Duezel
  • Lars Backman
  • Ulman Lindenberger
  • Martin Lövdén

Summary, in English

A widespread network involving cortical and subcortical brain structures forms the neural substrate of human spatial navigation. Most studies investigating plasticity of this network have focused on the hippocampus. Here, we investigate age differences in cortical thickness changes evoked by four months of spatial navigation training in 91 men aged 20-30 or 60-70 years. Cortical thickness was automatically measured before, immediately after, and four months after termination of training. Younger as well as older navigators evidenced large improvements in navigation performance that were partly maintained after termination of training. Importantly, training-related cortical thickening in left precuneus and paracentral lobule were observed in young navigators only. Thus, spatial navigation training appears to affect cortical brain structure of young adults, but there is reduced potential for experience-dependent cortical alterations in old age. (C) 2011 Elsevier Inc. All rights reserved.

Publiceringsår

2012

Språk

Engelska

Sidor

3389-3397

Publikation/Tidskrift/Serie

NeuroImage

Volym

59

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Psychology

Nyckelord

  • Spatial navigation
  • Aging
  • Cortical thickness
  • Plasticity

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1095-9572