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TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Publiceringsår: 2011
Språk: Engelska
Sidor: 272-274
Publikation/Tidskrift/Serie: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volym: 35
Nummer: 2
Dokumenttyp: Artikel i tidskrift
Förlag: Elsevier


TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.


  • Cancer and Oncology
  • TP53 mutation
  • 17p-deletion
  • Prognosis
  • Chronic lymphocytic leukemia


  • ISSN: 1873-5835

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