TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
Författare
Summary, in English
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
272-274
Publikation/Tidskrift/Serie
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volym
35
Issue
2
Fulltext
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cancer and Oncology
Nyckelord
- TP53 mutation
- 17p-deletion
- Prognosis
- Chronic lymphocytic leukemia
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1873-5835