Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): Molecular phylogeny, foregut anatomy and comparative toxinology

Summary, in English

The > 10,000 living venomous marine snail species [superfamily Conoidea Fleming, 1822] include cone snails (Conus), the overwhelming focus of research. Hastula hectica (Linnaeus, 1758), a venomous snail in the family Terebridae Morch, 1852 was comprehensively investigated. The Terebridae comprise a major monophyletic group within Conoidea. H. hectica has a striking radular tooth to inject venom that looks like a perforated spear; in Conus, the tooth looks like a hypodermic needle. H. hectica venom contains a large complement of small disulfide-rich peptides, but with no apparent overlap with Conus in gene superfamilies expressed. Although Conus peptide toxins are densely post-translationally modified, no post-translationally modified amino acids were found in any Hastula venom peptide. The results suggest that different major lineages of venomous molluscs have strikingly divergent toxinological and venom-delivery strategies. J. Exp. Zool. (Mol. Deu. Euol.) 308B: 744- 756, 2007. (c) 2007 Wiley-Liss, Inc.

• Författare: Julita S. Imperial; Yuri Kantor; Maren Watkins; Francisco M., III Heralde; Bradford Stevenson; Ping Chen; Karin M Hansson; Johan Stenflo; John-Paul Ownby; Philippe Bouchet; Baldomero M. Olivera
• Avdelning/ar: Klinisk kemi, Malmö
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 744-756
• Publikation/Tidskrift/Serie: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
• Volym: 308B
• Issue: 6
• Länkar: http://dx.doi.org/10.1002/jez.b.21195
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Medicinal Chemistry
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1552-5007