Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

fMRI for mapping the plastic somatotopy of primary somatosensory cortex - Development and clinical applications

Publiceringsår: 2009
Språk: Engelska
Publikation/Tidskrift/Serie: Lund University, Faculty of Medicine Doctoral Dissertation Series
Volym: 2009:119
Dokumenttyp: Doktorsavhandling
Förlag: Medical Radiation Physics, Lund University


Functional magnetic resonance imaging (fMRI) is a widely used tool for

studying brain function in vivo. The technique is based on acquiring brain

images sensitive to the physiological response following neural activation,

and hence, allows brain activity to be examined and documented.

In this thesis, methods for fMRI mapping of the primary somatosensory

cortex (S1) are optimised and subsequently applied in studies where a

plastic reorganisation of S1 is hypothesised.

Initially, the impact of spatial resolution and smoothing on fMRI data of

detailed S1 activation was investigated using a theoretical model of fMRI

performance. The impact of these parameters was also examined in healthy

volunteers where different fingers were mapped in S1. This was

accomplished using computer controlled and reproducible tactile

stimulation. It was found that both the optimal spatial resolution and

preferred level of smoothing were intimately coupled to the experiment’s


These results were utilised for monitoring sensory activation of S1 in three

cohorts where cortical reorganisation was anticipated: (i) In healthy

volunteers where the volar part of the forearm was anaesthetised, (ii) in

hand amputees and (iii) in subjects suffering from long-term exposure to

vibrating tools. In all these groups, evidence of plastic changes in the

sensorimotor system were found. This suggests that plastic processes could

be an underlying mechanism for the symptoms experienced in patients

following nerve injury and neuropathy.

Finally, alternative methods for mapping functional networks of the

sensorimotor cortex during rest were explored. We found that the resulting

networks were comparable to activation maps during a finger-tapping task,

although only partly overlapping. Such network maps could potentially add

to our understanding of brain plasticity in this region of the brain.

In conclusion, this work has improved the feasibility of monitoring plastic

reorganisation in S1. This may contribute to the process of rehabilitation in

patients suffering from sensory disorders following nerve injury and



Universitetssjukhuset MAS, Diagnistiskt Centrum, Ing 44, plan 2, rum 2005
  • Peter Lundberg


  • Radiology, Nuclear Medicine and Medical Imaging
  • smoothing
  • physiological noise
  • spatial resolution
  • primary somatosensory cortex
  • cortical reorganisation
  • brain plasticity
  • fMRI
  • partial volume effects


  • Medical Radiation Physics, Malmö
  • Jonas Svensson
  • Sören Mattsson
  • Göran Lundborg
  • ISSN: 1652-8220
  • ISBN: 978-91-86443-08-5

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen