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Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets

Publiceringsår: 2005
Språk: Engelska
Sidor: 343-348
Publikation/Tidskrift/Serie: Bulletin of the Veterinary Institute in Puławy
Volym: 49
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: National Veterinary Research Institute


The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated in the same way and time with physiological saline. The experimental and control groups were assigned to 6 age subgroups: 3, 14, 21, 35, 56 and 70 d of life. The animals from both groups were euthanised, then bone samples were collected and frozen at -25 degrees C until further analyses. Using dual-energy x-ray absorptiometry (DEXA method) bone mineral density of the femora was estimated. Additionally, 17-beta-oestradiol concentration in blood plasma was assayed using RIA-test. The obtained results indicate positive influence of enteral AKG administration on bone mineral density of the femur in piglets. Moreover, AKG increased the level of 17-beta-oestradiol in blood plasma in post-weaned piglets.


  • Zoology
  • 17-beta-oestradiol
  • bone mineral density
  • femur
  • piglets
  • alpha-ketoglutarate


  • ISSN: 0042-4870

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