Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Feedback control of Purkinje cell activity by the cerebello-olivary pathway.

In English

Författare

Summary, in English

The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis.

Avdelning/ar

Publiceringsår

2004

Språk

Engelska

Sidor

2999-3005

Publikation/Tidskrift/Serie

European Journal of Neuroscience

Volym

20

Issue

11

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Neurosciences

Nyckelord

  • climbing fibres
  • cerebellum
  • deep cerebellar nuclei
  • inferior olive
  • nucleo-olivary pathway

Status

Published

Forskningsgrupp

  • Neurophysiology

ISBN/ISSN/Övrigt

  • ISSN: 1460-9568