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Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gamma delta T-cell ligand T10

Författare

  • MG Rudolph
  • Christer Wingren
  • MP Crowley
  • YH Chien
  • IA Wilson

Summary, in English

T10 is a non-classical class Ib-like major histocompatibility complex (MHC) cell-surface antigen which binds directly to certain gammadelta T-cell receptors in the absence of any exogenous and endogenous ligands, such as peculiar lipids or glycolipids. The crystal structure at 2.5 Angstrom resolution of murine T10 was determined by molecular replacement using data from an almost perfectly twinned monoclinic crystal. The space group is P2(1), with unit-cell parameters a=78.2, b=70.0, c=139.2 Angstrom, beta=106.8degrees. Self-rotation function analysis and various intensity statistics revealed the presence of pseudo-merohedral twinning, but these tests underestimated the true twin fraction of alphasimilar or equal to0.46. Native Patterson analyses pointed to the presence of pseudo-translation among the four molecules present in the asymmetric unit. Data analysis, structure determination and model refinement are discussed.

Publiceringsår

2004

Språk

Engelska

Sidor

656-664

Publikation/Tidskrift/Serie

Acta Crystallographica. Section D: Biological Crystallography

Volym

60

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Structural Biology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1399-0047