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Intestinal bacteria and permeability during experimental acute pancreatitis in rats

Publiceringsår: 2006
Språk: Engelska
Sidor: 276-284
Publikation/Tidskrift/Serie: Annals of Gastroenterology
Volym: 19
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: Hellenic Society of Gastroenterology


Background: An increase in intestinal permeability and subsequent bacterial translocation has been demonstrated in

critical illness. Cellulose derivatives have in the past been shown to reduce gut leakage following liver resection.

Aims: The aim of the present study was to evaluate changes

in microbial counts in experimental acute pancreatitis and

the effect of pre-treatment with cellulose derivatives and

N-acetyl cysteine.

Subjects: 92 male Sprague Dawley rats.

Methods: Acute pancreatitis was induced by intraductal taurodeoxycholic acid infusion. Animals received oral pretreatment and were randomized to either sham operation

or the pancreatitis groups, with or without pre-treatment

with cellulose derivatives, the antioxidant or their combinations. Intestinal bacterial populations and permeability were evaluated using bacterial counts and Ussing chamber, respectively.

Results: The number of E. coli increased in the luminal content and ileal and colonic mucosa, but levels were restored to almost those seen in controls in all pre-treatment groups except for N-acetyl cysteine. When intestinal permeability was measured, none of the treatment groups showed significant differences compared to challenge, except for Nacetyl cysteine, which significantly increased permeability.

Conclusion: Pre-treatment with cellulose derivatives was

more efficient against disturbances in intestinal permeability and microbial populations than the antioxidant Nacetyl cysteine.


  • Clinical Medicine
  • dietary fibres
  • acute pancreatitis
  • bacterial counts
  • intestinal permeability


  • ISSN: 1108-7471

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