Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

High concentration of kynurenic acid in bile and pancreatic juice

Publiceringsår: 2009
Språk: Engelska
Sidor: 637-641
Publikation/Tidskrift/Serie: Amino Acids
Volym: 37
Nummer: 4
Dokumenttyp: Artikel i tidskrift
Förlag: Springer


Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive system, reaching 1,638 nM in the colon content. We suggest that the liver and pancreas affect the content of kynurenic acid in the lumen of the digestive tract.


  • Zoology
  • Gastric juice
  • Kynurenic acid
  • Bile
  • Pancreatic juice


  • ISSN: 0939-4451

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen