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High concentration of kynurenic acid in bile and pancreatic juice

In English

Författare

Summary, in English

Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive system, reaching 1,638 nM in the colon content. We suggest that the liver and pancreas affect the content of kynurenic acid in the lumen of the digestive tract.

Publiceringsår

2009

Språk

Engelska

Sidor

637-641

Publikation/Tidskrift/Serie

Amino Acids

Volym

37

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Zoology

Nyckelord

  • Gastric juice
  • Kynurenic acid
  • Bile
  • Pancreatic juice

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0939-4451