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Gene expression profile of mouse bone marrow stromal cells determined by cDNA microarray analysis

In English

Författare

  • Georg Wieczorek
  • Christine Steinhoff
  • Ralph Schulz
  • Marina Scheller
  • Martin Vingron
  • H-Hilger Ropers
  • Ulrike Nuber

Summary, in English

Bone marrow stromal cells (BMSC) have gained increased attention because of their multipotency and adult stem cell character. They have been shown to differentiate into other cell types of the mesenchymal lineage and also into non-mesenchymal cells. The exact identity of the original cells, which are isolated from bone marrow by their selective adherence to plastic, remains unknown to date. We have established and characterized mouse BMSC cultures and analyzed three independent samples by cDNA microarrays. The expression profile was compared with two previous expression studies of human BMSC and revealed a high degree of concordance between different techniques and species. To gain clues about the positional context and biology of the isolated cells within the bone marrow stroma, we searched our data for genes that encode proteins of the extracellular matrix, cell adhesion proteins, cytoskeletal proteins and cytokines/cytokine receptors. This analysis revealed a close association of BMSC with vascular cells and indicated that BMSC resemble pericytes.

Publiceringsår

2003

Språk

Engelska

Sidor

227-237

Publikation/Tidskrift/Serie

Cell and Tissue Research

Volym

311

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Cell Biology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1432-0878