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Robustness of metabolic maps

Publiceringsår: 2004
Språk: Engelska
Sidor: 589-593
Publikation/Tidskrift/Serie: Journal of Bioinformatics and Computational Biology
Volym: 2
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: Imperial College Press


With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In order to be able to use incomplete data for metabolic reconstruction, the inherent properties of this procedure need to be investigated. In this short note, we describe the robustness and predictive power of metabolic reconstructions using partial information from Schizosaccharomyces pombe. We also discuss the implications of the results on reference genome projects as well as other large-scale sequencing data.


  • Biological Sciences
  • Metabolic reconstruction metabolic maps genome analysis robustness analysis biochemical pathways


  • Microbial Ecology
  • ISSN: 0219-7200

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