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Fabrication of Microfluidic Platform with Optimized Fluidic Network toward On-Chip Parallel Systematic Evolution of Ligands by Exponential Enrichment Process

In English

Författare

  • Tae Kyung Kim
  • Sang Wook Lee
  • Ji-Young Ahn
  • Thomas Laurell
  • So Youn Kim
  • Ok Chan Jeong

Summary, in English

This paper presents the design and fabrication of a microplatform with the optimal fluidic network for an on-chip parallel "systematic evolution of ligands by exponential enrichment" (SELEX) process. The effectiveness of the optimized fluidic network for on-chip five-plex aptamer screening was verified by measuring the airflow rate at the elution ports and visualizing the specific elution during the SELEX process. The proposed device with an optimally designed hydraulic resistance-balanced channel network could be feasible and utilized as a multiplex selection module for a parallel SELEX process. (c) 2011 The Japan Society of Applied Physics

Publiceringsår

2011

Språk

Engelska

Sidor

05-06

Publikation/Tidskrift/Serie

Japanese Journal of Applied Physics

Volym

50

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Medical Engineering

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0021-4922