Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis.

Publiceringsår: 2012
Språk: Engelska
Sidor: 1-7
Publikation/Tidskrift/Serie: Journal of Inorganic Biochemistry
Volym: 108
Nummer: March
Dokumenttyp: Artikel i tidskrift
Förlag: Elsevier


A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.


  • Pharmacology and Toxicology
  • Modified polyamines
  • Pt(II) / Pd(II) complexes
  • Raman spectroscopy
  • Infrared spectroscopy
  • Anticancer


  • Biogenic Amines
  • ISSN: 1873-3344

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen