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Feeding strategies for E-coli fermentations demanding an enriched environment

In English

Författare

Summary, in English

The addition of a carbon nutrient feed to a fed-batch cultivation is often not enough to obtain satisfactory growth and/or production. In some cases, an additional feed with for example supplementary amino acids or complex media is required. This work presents the development of feeding strategies where more than one feed is required and the knowledge of the growth requirements is low. Simulations and cultivations with E. coli are shown using the proposed feed controllers which are based on a probing control concept. The strategies work well and they can be used to shorten the process development phase considerably.

Publiceringsår

2007

Språk

Engelska

Sidor

13-25

Publikation/Tidskrift/Serie

Bioprocess and Biosystems Engineering

Volym

30

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Control Engineering

Nyckelord

  • Escherichia coli
  • complex medium
  • amino acid
  • fed-batch cultivation
  • fermentation process
  • feeding strategy

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1615-7605