Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity

Författare

  • Jure Piskur
  • Michael Sandrini
  • W. Knecht
  • Birgitte Munch-Petersen

Summary, in English

Abstract

Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.

Publiceringsår

2004

Språk

Engelska

Sidor

41339-41339

Publikation/Tidskrift/Serie

FEBS Letters

Volym

560

Issue

1-3

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Biological Sciences

Nyckelord

  • nucleic acid precursors
  • evolution
  • enzyme
  • kinases

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1873-3468