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New directions of miniaturization within the proteomics research area

Publiceringsår: 2003
Språk: Engelska
Sidor: 3521-3532
Publikation/Tidskrift/Serie: Electrophoresis
Volym: 24
Nummer: 21
Dokumenttyp: Artikel i tidskrift
Förlag: John Wiley & Sons


An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel- and liquid-phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing plays a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.


  • Medical Engineering
  • Analytical Chemistry
  • proteomics
  • miniaturization
  • protein expression profiling
  • review


  • ISSN: 0173-0835

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