Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

Intraduodenal infusion of alpha-ketoglutarate decreases whole body energy expenditure in growing pigs

  • Peter Junghans
  • Michael Derno
  • Stefan Pierzynowski
  • Ulf Hennig
  • Paul Eberhard Rudolph
  • Wolfgang B. Souffrant
Publiceringsår: 2006
Språk: Engelska
Sidor: 489-496
Publikation/Tidskrift/Serie: Clinical Nutrition
Volym: 25
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: Elsevier


Background & aims: alpha-Ketoglutarate (AKG) has been suggested to play a particular role as an oxidative fuel for the gut, and thus may have a sparing function for fuels such as glutamate and aspartate. Using the pig model we aimed to quantify how the route of administration (intravenous, i.v.; intragastric, i.g.; intraduodenal, i.d.) affects AKG utilization, whole body energy expenditure (EE) and nutrient oxidation. Methods: Pigs (15 kg) were supplied with a complete nutrient solution (NS) via catheters. To explore the metabolic effects of AKG, 1.0 g AKG kgBW(-1) d(-1) was infused simultaneously with the NS using either the i.d., i.v. or i.g. route. [1-C-13]AKG (15 mg kgBW(-1)) was infused i.d., i.v. or i.g., respectively, for 3 h. AKG utilization (AKG UTIL) was estimated as AKG UTIL = 100-C-13 recovery (% of C-13 dose). C-13 recovery was calculated from the C-13 enrichment in breath CO2 and the whole-body CO2 production. Results: AKG infusion and NS via the i.d. route resulted in a reduced AKG UTIL (40.1 +/- 6.7) as compared to the i.v. route (62.9 +/- 2.4, P < 0.001) and i.g. route (62.3 +/- 1.6, P < 0.001). The total EE was lower with the i.d. route of AKG and NS (745 +/- 68 kJ kgBW(-0.62) d(-1)) as compared to the i.v. route (965 +/- 54 kJ kgBW(-0.62) d(-1), P < 0.005) and i.g. route (918 +/- 43 kJ kgBW(-0.62) d(-1), P < 0.005). Carbohydrate oxidation was increased with the i.d. route (38.2g +/- 3.4 kg BW-0.62 d(-1)) as compared to the i.v. route (27.8 +/- 2.9g kg BW-0.62 d(-1), P < 0.08) and i.g. route (23.9 +/- 8.5g kg BW-0.62 d(-1), P < 0.05). Fat oxidation was decreased (2.1 +/- 1.9 g kgBW(-0.62) d(-1); P < 0.001) with the i.d. route as compared to the i.v. route (11.5 coproduct 1.4g kgBW(-0.62) d(-1), P < 0.001) and i.g. route (11.9 +/- 3.1 g kgBW(-0.62) d(-1), P < 0.001). Conclusions: The i.d. infusion of AKG in combination with the NS affected the whole body EE and nutrient oxidation, in comparison to that obtained with the i.v. and i.g. routes. It was concluded that the i.d. administration of AKG markedly controlled the nutrient partitioning in the oxidation processes. Finally, in contrary to the observations with glutamine or glutamate, a considerable percentage of the AKG infusion was retained in the body irrespective of the route of administration. (C) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.


  • Nutrition and Dietetics
  • energy expenditure
  • alpha-ketoglutarate
  • administration route
  • pig model


  • ISSN: 1532-1983

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen