Heme A biosynthesis

Summary, in English

Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.

• Författare: Lars Hederstedt
• Avdelning/ar: Molekylär cellbiologi
• Publiceringsår: 2012
• Språk: Engelska
• Sidor: 920-927
• Publikation/Tidskrift/Serie: Biochimica et Biophysica Acta - Bioenergetics
• Volym: 1817
• Issue: 6
• Länkar: http://dx.doi.org/10.1016/j.bbabio.2012.03.025
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Microbiology
• Nyckelord: Cytochrome biogenesis; Heme synthesis; CtaA; COX15; Oxidase assembly
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0005-2728