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Inflammation and cholesterol

Publiceringsår: 2002
Språk: Engelska
Sidor: 18-25
Publikation/Tidskrift/Serie: European Heart Journal Supplements
Volym: 4
Nummer: Suppl A
Dokumenttyp: Artikel i tidskrift
Förlag: Oxford University Press


Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.


  • Cardiac and Cardiovascular Systems
  • lipoproteins
  • atherosclerosis
  • macrophages
  • immunity
  • smooth muscle
  • cells


  • Experimental Cardiovascular Research Unit
  • ISSN: 1520-765X

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