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Absolute quantification of cerebral blood flow in normal volunteers: Correlation between Xe-133SPECT and dynamic susceptibility contrast MRI

Publiceringsår: 2007
Språk: Engelska
Sidor: 913-920
Publikation/Tidskrift/Serie: Journal of Magnetic Resonance Imaging
Volym: 26
Nummer: 4
Dokumenttyp: Artikel i tidskrift
Förlag: John Wiley & Sons


Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT were 85 +/- 23 mL/(min 100 g) and 40 +/- 8 mL/(min 100 g), respectively (mean +/- SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 CBF(Xe) - 7.9 (CBF in units of mL/(min 100 g)). Conclusion: A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T).


  • Radiology, Nuclear Medicine and Medical Imaging
  • magnetic
  • cerebral blood flow
  • dynamic susceptibility contrast
  • resonance imaging
  • perfusion
  • Xe-133SPECT


  • ISSN: 1522-2586

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