SPECT findings in children with specific language impairment.
Författare
Summary, in English
Findings from 99mTc-HMPAO SPECT measurements at rest in a group of 19 school-age children with specific language
impairment (SLI) were compared to a group of 12 children with attention-deficit hyperactivity disorder (ADHD). The
regional cerebral blood flow (CBF) distributions were different in the two groups. Children with SLI showed significantly lower CBF values in the right parietal region and in the subcortical region compared to the ADHD group. In addition, the SLI group had symmetric CBF distributions in the left and right temporal regions, whereas the ADHD group showed the usual asymmetry with left-sided hemispheric predominance in the temporal regions. The findings give further evidence for anomalous neurodevelopment with deviant hemispheric lateralization as an important factor in the aetiology of SLI. They also point to the role of subcortical structures in language impairment in childhood. Earlier focus on cortical structures in SLI research needs to be widened to include subcortical regions as well.
impairment (SLI) were compared to a group of 12 children with attention-deficit hyperactivity disorder (ADHD). The
regional cerebral blood flow (CBF) distributions were different in the two groups. Children with SLI showed significantly lower CBF values in the right parietal region and in the subcortical region compared to the ADHD group. In addition, the SLI group had symmetric CBF distributions in the left and right temporal regions, whereas the ADHD group showed the usual asymmetry with left-sided hemispheric predominance in the temporal regions. The findings give further evidence for anomalous neurodevelopment with deviant hemispheric lateralization as an important factor in the aetiology of SLI. They also point to the role of subcortical structures in language impairment in childhood. Earlier focus on cortical structures in SLI research needs to be widened to include subcortical regions as well.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
316-326
Publikation/Tidskrift/Serie
Cortex
Volym
41
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Neurology
Nyckelord
- lateralization
- ADHD
- specific language impairment
- thalamus
- language disorders
- SPECT
- basal ganglia
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1973-8102