Anders Björklund
Titel
professor
Organisation
046-2220540
Anders [dot] Bjorklund [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- Cell therapy for Parkinson's disease: what next?
- Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease
- Generation of induced neurons via direct conversion in vivo.
- TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
- Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
- Trophic Factor Gene Therapy for Parkinson's Disease
- 2012
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo.
- Amphetamine-induced rotation and l-DOPA-induced dyskinesia in the rat 6-OHDA model: A correlation study.
- Comparison of the behavioural and histological characteristics of the 6-OHDA and alpha-synuclein rat models of Parkinson's disease
- Generation of Transplantable Striatal Projection Neurons from Human ESCs.
- Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons.
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.
- Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease.
- Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts
- α-Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons.
- 2011
- Cell Therapeutics in Parkinson's Disease.
- Direct conversion of human fibroblasts to dopaminergic neurons.
- GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.
- Gene therapy for Parkinson's disease shows promise.
- Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio
- 2010
- Characterisation of Behavioural and Neurodegenerative Changes Induced by Intranigral 6-Hydroxydopamine Lesions in a Mouse Model of Parkinson's Disease
- Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
- Characterization of Lewy Body Pathology in 12-and 16-Year Old Intrastriatal Mesencephalic Grafts Surviving in a Patient with Parkinson's Disease
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.
- Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells
- Glial Cell Derived Neurotrophic Factor Does not Provide Neuroprotection Against Alpha-Synuclein-Induced Toxicity in a Rat Model of Parkinson's Disease
- Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia
- New Mouse Models for Studying Postnatal Role of GDNF In Vivo
- Recent Advances In Parkinson'S Disease: Translational And Clinical Research Preface
- Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
- Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants
- The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
- The Role of Norepinephrine Neurons in Motor Symptoms of Parkinson's Disease and Development of L-DOPA-Induced Dyskinesia
- Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.
- Viral vector-mediated overexpression of alpha-synuclein as a progressive model of Parkinson's disease
- Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.
- 2009
- Differential Infectivity Following Basal Ganglia Administration of Differing AAV Serotypes in Nonhuman Primates
- Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
- Gene therapy for dopamine replacement in Parkinson's disease.
- Identification of Transplantable Dopamine Neuron Precursors at Different Stages of Midbrain Neurogenesis.
- Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
- Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
- Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.
- Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT(1A) and 5-HT(1B) receptor agonists in the rat Parkinson model.
- Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts
- 2008
- Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
- Embryonic dopaminergic precursors can be isolated at different states of differentiation and function upon grafting into an animal model of Parkinson's disease
- Gene therapy for Parkinson's disease
- In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
- Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
- Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
- Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.
- 2007
- Dopamine neuron systems in the brain: an update
- Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.
- Fifty years of dopamine research.
- In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.
- Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
- The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
- 2006
- Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.
- Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
- Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.
- 2005
- Cell therapy for Parkinson's disease: problems and prospects.
- Cell transplantation in Parkinson's disease: how can we make it work?
- Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
- Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
- Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
- Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
- Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor.
- Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.
- Parkinson's disease: Viral vector delivery of parkin generates model results in rats.
- Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
- 2004
- Cell Therapy in Parkinson's Disease.
- Localized striatal delivery of GDNF as a treatment for Parkinson disease.
- Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.
- Special Issue Stem Cells - Preface
- Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression.
- 2003
- Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.
- Neural transplantation for the treatment of Parkinson's disease
- Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions.
- Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
- Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro.
- Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model.
- 2002
- Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.
- Differentiation of the RN33B Cell Line into Forebrain Projection Neurons after Transplantation into the Neonatal Rat Brain.
- Dyskinesias following neural transplantation in Parkinson's disease.
- Evaluation of Tet-on system to avoid transgene downregulation in ex vivo gene transfer to the CNS
- Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.
- L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function.
- Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain.
- Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector.
- Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
- Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.
- Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon.
- Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
- Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections.
- 2001
- Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
- Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
- Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury
- 2000
- Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease
- Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts
- EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum
- Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
- Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
- Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
- Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
- Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement
- 1999
- Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
- Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants
- Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
- Sequential bilateral transplantation in Parkinson's disease: effects of the second graft
- 1998
- 1997
- 1994
- 1987
- 1983
- Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation.
- Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cells implanted in different brain sites
- Intracerebral grafting of neuronal cell suspensions. III. Activaty of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism
- Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral implants of nigral cell suspensions in different forebrain sites
- Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensions.
- Intracerebral grafting of neuronal cell suspensions. VI. Survival and growth of intrahippocampal implants of septal cell suspensions
- Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippccampus reinnervated by septal suspension implants
- Intracerebral grafting of neuronal cell suspensions. VIII. Cell survival and axonal outgrcwth of dcpaminergic and cholinergic cells in the aged brain.
redaktör
- 1994
