David Bryder
Titel
forskare, Docent
Organisation
046-2223951
0706423951
David [dot] Bryder [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.
- Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation.
- SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
- 2012
- 2011
- Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
- Flow cytometry-based identification of immature myeloerythroid development.
- Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
- The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor
- Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.
- 2010
- Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia
- Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
- Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
- Load and lock: the molecular mechanisms of B-lymphocyte commitment.
- Shaping up a lineage-lessons from B lymphopoesis.
- Single cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
- 2009
- A Novel Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia Locates the Erythroid Defect at CFU-E/Proerythroblast Transition
- Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML
- Hematopoietic stem cell ageing is uncoupled from p16(INK4A)-mediated senescence.
- Niche Recycling through Division-Independent Egress of Hematopoietic Stem Cells.
- Niche recycling through division-independent egress of hematopoietic stem cells
- 2008
- A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal.
- B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
- Deciphering developmental stages of adult myelopoiesis.
- EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors
- Kit regulates maintenance of quiescent hematopoietic stem cells.
- NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
- 2007
- Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
- Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
- Endoglin is not Critical for Hematopoietic Stem Cell Engraftment and Reconstitution, but Regulates Adult Erythroid Development.
- Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development
- Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
- Hematopoietic stem cell aging: Mechanism and consequence
- Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
- The CXCL12, periostin and CCL9 genes are direct targets for early B-cell factor (EBF) in OP-9 stroma cells.
- 2006
- Hematopoietic stem cells: the paradigmatic tissue-specific stem cell
- Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.
- Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
- Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors
- Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
- 2005
- Cell intrinsic alterations underlie hematopoietic stem cell aging
- Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.
- IFN-{gamma} Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells.
- Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
- Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
- Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated recipients.
- Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
- 2004
- 2003
- Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis.
- Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.
- Molecular regulation of hematopoietic stem cells
- 2002
- Efficient Oncoretroviral Transduction of Extended Long-Term Culture-Initiating Cells and NOD/SCID Repopulating Cells: Enhanced Reconstitution with Gene-Marked Cells Through an Ex Vivo Expansion Approach.
- Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.
- Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.
- 2001
- Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation
- Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells
- Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
- 2000
- 1999
