Lars Rönnstrand

författare

• 2013
  • Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.
  • The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.
• 2012
  • 3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells
  • Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3
  • FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
  • HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed.
  • SRC is a signaling mediator in FLT3-ITD-but not in FLT3-TKD-positive AML
  • Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling.
  • Stem cell factor receptor/c-Kit: from basic science to clinical implications
  • Suppressor Of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated Tyr 591 and Tyr 919 of Flt3.
• 2011
  • C-KIT Signaling Depends on Microphthalmia-Associated Transcription Factor for Effects on Cell Proliferation.
  • Impact of gene dosage, loss of wild type allele and FLT3 ligand on Flt3-ITD induced myeloproliferation.
  • Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
  • Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice.
  • Protein tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling
  • Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase
• 2009
  • A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML
  • A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival.
  • Oncogenic flt3 receptors display different specificity and kinetics of autophosphorylation.
  • Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3.
  • Signaling by the Platelet-Derived Growth Factor Receptor Family
  • The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.
  • The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.
• 2008
  • GAB2 is involved in differential pi3-kinase signaling by two splice forms of C-kit.
  • Identification Of Three Tyrosine Residues Of Importance For Survival Signaling Of Flt3 Ito Through Gab2
  • Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.
  • The D816V Mutation of C-Kit Circumvents a Requirement for Sire Family Kinases in C-Kit Mediated Signal Tranduction and Transformation.
  • The Identification of a Novel Stromal Stem/Progenitor Cell Phenotype in the Human Adult Prostate
  • The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.
• 2007
  • Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.
  • Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
• 2006
  • Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
  • Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism.
  • Direct binding of Cbl to Tyr(568) and Tyr(936) of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
  • Identification of Y589 and Y599 in the juxamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
  • Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine
  • Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor
  • Receptor association and tyrosine phosphorylation of S6 kinases
  • Receptor association and tyrosine phosphorylation of S6 kinases
  • The stem cell factor receptor/c-Kit as a drug target in cancer.
• 2005
  • C-Kit signal transduction and involvement in cancer
• 2004
  • Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
  • Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin EP4-R essential for agonist-induced beta-arrestin1 recruitment that differs from the apparent principal phosphorylation site.
  • Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins
  • Signal transduction via the stem cell factor receptor/c-Kit.
  • Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
  • p38-MAPK Signals Survival by Phosphorylation of Caspase-8 and Caspase-3 in Human Neutrophils.
• 2003
  • Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications
  • Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
  • Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin
  • Dysfunctionality of a tobacco mosaic virus movement protein mutant mimicking threonine 104 phosphorylation.
  • Ezrin is a substrate for Lck in T cells.
  • Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
  • Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases
  • Identification of protein tyrosine phosphatases associating with the PDGF receptor
  • Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF.
  • Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.
  • Src family kinases are involved in the differential signaling from two splice-forms of c-Kit.
  • The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.
• 2002
  • Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration
  • EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor
  • Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.
• 2001
  • Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF
  • Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
  • Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block
• 2000
  • Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis
  • DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation
  • Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
  • TNF-alpha suppresses the PDGF beta-receptor kinase
• 1999
  • Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein
  • Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes
  • Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
  • Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding
  • Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis
  • Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
  • SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis
• 1998
  • Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins
  • Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
  • Molecular basis for the dominant white phenotype in the domestic pig
• 1997
  • Association of coatomer proteins with the beta-receptor for platelet-derived growth factor
  • Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release
  • PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation
  • Phosphorylation of a 72-kDa protein in PDGF-stimulated cells which forms complex with c-Crk, c-Fyn and Eps15
  • Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296
• 1996
  • Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol
  • Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
  • Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis
• 1995
  • Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors
  • Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells
• 1994
  • A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis
  • A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex
  • Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
  • Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
  • Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation
• 1993
  • Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
  • Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C
• 1992
  • Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma
• 1991
  • Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events
  • Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan
  • Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes
• 1990
  • Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides
• 1989
  • Dimerization of B type PDGF receptors occurs after ligand binding and is closely associated with receptor kinase activation
  • Platelet-derived growth factor receptors in the kidney - an upregulated expression in renal inflammation
• 1988
  • A glioma-derived PDGF A chain homodimer has different functional activities than a PDGF AB heterodimer purified from human platelets
  • Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types
  • Biosynthesis and intracellular processing of the receptor for platelet-derived growth factor.
  • Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor
  • Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation
  • Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions
  • Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing
• 1987
  • Purification of the receptor for platelet-derived growth factor from porcine uterus
  • Tissue distribution of macrophages, class II transplantation antigens, and receptors for platelet-derived growth factor in normal and rejected human kidneys
• 1983
  • Characterization of the receptor for platelet-derived growth factor on human fibroblasts