Christer Larsson

författare

• 2012
  • Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
  • Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death.
  • PKCα Binds G3BP2 and Regulates Stress Granule Formation Following Cellular Stress.
• 2011
  • Protein kinase Cα suppresses the expression of STC1 in MDA-MB-231 breast cancer cells
• 2010
  • B cell activation by outer membrane vesicles--a novel virulence mechanism.
  • PKC alpha expression is a marker for breast cancer aggressiveness
• 2009
  • PKC{delta} supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway.
  • Protein Kinase C delta Supports Survival of MDA-MB-231 Breast Cancer Cells by Suppressing the ERK1/2 Pathway
• 2008
  • New insights into PKC family affairs: three novel phosphorylation sites in PKCepsilon and at least one is regulated by PKCalpha.
  • PKCepsilon binds peripherin and induces its aggregation which is accompanied by apoptosis of neuroblastoma cells.
  • Protein kinase Cepsilon is important for migration of neuroblastoma cells
• 2007
  • Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax.
  • Comparison of the PKCalpha and the PKCepsilon C1b Domains: Identification of Residues Critical for PKCepsilon-mediated Neurite Induction.
  • Identification of acidic amino acid residues in the PKCalpha V5 domain that contribute to its insensitivity to diacylglycerol.
  • Identification of acidic amino acid residues in the protein kinase C alpha V5 domain that contribute to its insensitivity to diacylglycerol
• 2006
  • Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling.
  • Protein kinase C and the regulation of the actin cytoskeleton.
• 2005
  • Distinct roles of PKC isoforms in NCAM-mediated neurite outgrowth
  • Identification of conserved amino acids N-terminal of the PKCeC1bdomain crucial for PKCe-mediated induction of neurite outgrowth.
• 2004
  • A possible role for p190RhoGAP in PKCepsilon-induced morphological effects.
  • Autophosphorylation suppresses, whereas kinase inhibition augments, the translocation of PKCa in response to diacylglycerol.
  • Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms.
  • Identification of an amino acid residue in the PKC C1b domain crucial for its localisation to the Golgi network.
  • Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway.
  • Regulation of ADAM12 cell-surface expression by protein kinase C epsilon
  • The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon
• 2003
  • A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells.
  • ADAM12/syndecan-4 signaling promotes beta(1) integrin-dependent cell spreading through protein kinase C alpha and RhoA
  • Expression of trkB in Human Neuroblastoma in Relation to MYCN Expression and Retinoic Acid Treatment.
  • The catalytic domain limits the translocation of protein kinase C alpha in response to increases in Ca2+ and diacylglycerol.
  • The regulatory domain of protein kinase Ctheta localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells.
• 2002
  • A role for PKC-epsilon in Fc gamma R-mediated phagocytosis by RAW 264.7 cells
  • Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells.
  • Leukotriene D-4 activates MAPK through a Ras-independent but PKC epsilon-dependent pathway in intestinal epithelial cells
  • Leukotriene D-4 induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKC delta
  • Protein Kinase Cepsilon Actin-binding Site Is Important for Neurite Outgrowth during Neuronal Differentiation.
• 2001
  • A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells
  • ADAM 12-induced syndecan-beta 1 integrin mediated cell spreading is regulated by protein kinase C alpha, PI-3 kinase and Rac
  • Differences in early and late responses between neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y neuroblastoma cells
  • The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells
• 2000
  • Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation
• 1999
  • Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells
  • Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells
  • PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells
  • The basic helix-loop-helix transcription factor dHAND, a marker gene for the developing human sympathetic nervous system, is expressed in both high- and low-stage neuroblastomas
• 1998
  • Acute ethanol exposure attenuates expression of junD in human neuroblastoma cells
  • Carbachol-stimulated Ca2+ increase in single neuroblastoma SH-SY5Y cells: effects of ethanol
  • Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH-SY5Y cells
  • Stimulation of muscarinic receptors induces expression of individual fos and jun genes through different transduction pathways
• 1997
  • Acute effects of D-1 and D-2-receptor agonist and antagonist drugs on somatostatin binding, inhibition of adenylyl cyclase activity and accumulation of inositol 1,4,5-trisphosphate in the rat striatum
  • Characterization of phospholipase D activation by muscarinic receptors in human neuroblastoma SH-SY5Y cells
  • Effects of ethanol on muscarinic receptor-stimulated c-fos expression in human neuroblastoma cells
• 1996
  • Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells
  • Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells
  • Regulation of phospholipase D activity in neuroblastoma cells
• 1995
  • Calmidazolium inhibits muscarinic receptor-mediated PLC activation in SH-SY5Y cells
  • Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells
• 1994
  • Adaptation of signal transduction in brain
  • Mechanisms of muscarinic receptor-stimulated expression of c-fos in SH-SY5Y cells
  • Muscarinic receptor-stimulated expression of c-fos in neuroblastoma cells
• 1993
  • An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells
  • Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations
  • Evaluation of ethanol effects on PLC signal transduction pathways using cell lines of neuronal origin
• 1992
  • Activation of protein kinase C in permeabilized human neuroblastoma SH-SY5Y cells