Thoas Fioretos

författare

• 2013
  • SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
  • Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.
• 2012
  • Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations(a).
  • Whole-exome sequencing of pediatric acute lymphoblastic leukemia.
• 2011
  • Fusion Gene Microarray Reveals Cancer Type-Specificity Among Fusion Genes
  • SMAD4 binds HOXA9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by HOXA9 and leukemia transformation.
• 2010
  • Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.
  • Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
  • Integrative analysis of gene expression and copy number alterations using canonical correlation analysis
  • Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.
  • Modeling the human 8p11-myeloproliferative syndrome in immuno-deficient mice.
  • Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice
  • Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.
  • SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation
  • The Proportion of Ph+CD34(+)CD38(neg) Leukemic Stem Cells In the Bone Marrow of Newly Diagnosed Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase (CP) Is Variable and Correlates with High Sokal Risk, High Leukocyte Count, Low Hemoglobin Concentration, Splenomegaly and Increased Hematological Toxicity During Initial TKI Therapy Data From a Randomized Phase II NordCML006 Study
  • The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias
• 2009
  • Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage
  • Relapsed Childhood High Hyperdiploid Acute Lymphoblastic Leukemia: Genome-Wide Screening Reveals the Presence of Preleukemic Ancestral Clones and the Secondary Nature of Microdeletions and RTK-RAS Mutations
  • SMAD4 as a therapeutic target in hoxa9-related leukemia
  • The DNA methylome of pediatric acute lymphoblastic leukemia.
  • The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus.
• 2008
  • An improved method for detecting and delineating genomic regions with altered gene expression in cancer
  • BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias.
  • Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation.
  • Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia
  • Recurrent and multiple bladder tumors show conserved expression profiles.
  • The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia
  • The hypermethylome of pediatric acute lymphoblastic leukemia
• 2007
  • Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region
  • Cytogenetic evolution patterns in CML post-SCT.
  • Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells
  • Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome.
  • Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status.
  • Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies
  • Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3
• 2006
  • Cross-platform classification in microarray-based leukemia diagnostics
  • Cross-platform classification in microarray-based leukemia diagnostics.
  • Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia.
  • High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration.
  • Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia.
  • MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene
  • Mechanisms underlying neoplasia-associated genomic rearrangements
  • Meta- and synchronous urothelial carcinomas with divergent genomic profiles show highly similar gene-expression profiles
  • Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.
• 2005
  • Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia.
  • Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia.
  • Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations
  • Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.
• 2004
  • Approximate geodesic distances reveal biologically relevant structures in microarray data
  • Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients.
  • Establishment and phenotypic characterization of human U937 cells with inducible P210 BCR/ABL expression reveals upregulation of CEACAM1 (CD66a).
  • Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies.
  • Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays.
  • The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats.
• 2003
  • A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23).
  • Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate.
  • Cytogenetic and Molecular Genetic Evolution of Philadelphia-Chromosome-Positive Chronic Myeloid Leukaemia
  • Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia.
  • MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes
  • Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.
  • Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies. a multicolor and locus-specific fluorescence in situ hybridization study.
• 2002
  • Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.
  • Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15).
  • Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.
  • Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.
  • RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): Identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression.
• 2001
  • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder
  • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL
  • Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
  • Isodicentric 7p, idic(7)(q11.2), in acute myeloid
  • Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies
  • The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology
• 2000
  • Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements
  • RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13)
• 1999
  • Cytogenetic polyclonality in hematologic malignancies
  • Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations
• 1998
  • ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders
• 1997
  • BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
  • Poor survival in t(8;21) (q22;q22)-associated acute myeloid leukaemia with leukocytosis
• 1996
  • Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha
  • Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
  • Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes
  • t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia
• 1995
  • Regional localization and developmental expression of the BCR gene in rodent brain
  • Standpoint on imprinting of BCR and ABL
• 1994
  • Cellular interactions of CRKL, and SH2-SH3 adaptor protein
  • Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)
  • Molecular analysis of simple variant translocations in acute promyelocytic leukemia
  • No evidence for genomic imprinting of the human BCR gene
• 1993
  • CRK proto-oncogene maps to human chromosome band 17p13
  • Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia
• 1992
  • Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia
  • Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts
  • Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.
  • Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)
• 1991
  • An EcoRI polymorphism at the insulin receptor locus on a fragment comprising exons 4 to 8
  • Molekylär medicin: Molekylärgenetisk metodik avslöjar mekanismerna bakom tumörutveckling
  • New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia
• 1990
  • Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement