Lars Björck

författare

• 2013
  • IgG-binding bacterial proteins and pathogenesis.
• 2012
  • Antibody orientation at bacterial surfaces is related to invasive infection.
  • Streptococcal surface proteins activate the contact system and control its antibacterial activity.
  • Streptococcus pyogenes in human plasma: adaptive mechanisms analyzed by mass spectrometry based proteomics.
  • V-ATPase-mediated phagosomal acidification is impaired by Streptococcus pyogenes through Mga-regulated surface proteins.
• 2011
  • Activation of the contact system at the surface of Fusobacterium necrophorum: a possible virulence mechanism in Lemierre's syndrome.
  • Antibacterial activity of the contact and complement systems is blocked by SIC, a protein secreted by Streptococcus pyogenes.
  • Binding of albumin promotes bacterial survival at the epithelial surface.
  • Heparin-binding protein: A diagnostic marker of acute bacterial meningitis.
  • The factor H-binding fragment of PspC as a vaccine antigen for the induction of protective humoral immunity against experimental pneumococcal sepsis
• 2010
  • Erysipelas Caused by Group A Streptococcus Activates the Contact System and Induces the Release of Heparin-Binding Protein.
  • Heparin-Binding Protein: A Potential Biomarker in Sepsis? Reply
  • Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.
  • Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant
  • Streptococcal protein SIC: An anti-inflammatory virulence determinant.
  • Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes
• 2009
  • Bacterial surface protein L binds and inactivates neutrophil proteins S100A8/A9.
  • Heparin-binding protein: an early marker of circulatory failure in sepsis.
  • SufA - a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation.
  • Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
  • Treatment of invasive streptococcal infection with a peptide derived from human high molecular weight kininogen.
• 2008
  • Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.
  • IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential.
  • Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.
  • IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.
  • Immune-response against Streptococcus pyogenes in the development of abdominal aortic aneurysm - A population-based case-control study
  • Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid
  • Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring
• 2007
  • Blocking of experimental arthritis by cleavage of IgG antibodies in vivo
  • Blocking of experimental arthritis by cleavage of IgG antibodies in vivo.
  • Deoxyribonucleoside kinases activate nucleoside antibiotics in severe pathogenic bacteria.
  • M1 protein of Streptococcus pyogenes increases production of the antibacterial CXC chemokine MIG/CXCL9 in pharyngeal epithelial cells
  • Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation.
  • The CXC Chemokine MIG/CXCL9 Is Important in Innate Immunity against Streptococcus pyogenes.
  • The dual role of the contact system in bacterial infectious disease
• 2006
  • Streptococcal M protein: a multipotent and powerful inducer of inflammation.
  • Streptococcus pyogenes bacteria modulate membrane traffic in human neutrophils and selectively inhibit azurophilic granule fusion with phagosomes.
  • The contact system-a novel branch of innate immunity generating antibacterial peptides.
• 2005
  • The protein expression of Streptococcus pyogenes is significantly influenced by human plasma.
• 2004
  • Activation of the complement system generates antibacterial peptides.
  • Antimicrobial activities of heparin-binding peptides.
  • Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin
  • Down-modulation of the antigen receptor by a superantigen for human B cells
  • Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for igg cleavage due to exosite binding.
  • Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes.
  • Low Antibody Levels against Cell Wall-Attached Proteins of Streptococcus pyogenes Predispose for Severe Invasive Disease.
  • M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage
  • SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1.
  • Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
  • Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG
  • Whole-body autoradiography reveals that the Peptostreptococcus magnus immunoglobulin-binding domains of protein L preferentially target B lymphocytes in the spleen and lymph nodes in vivo.
  • alpha 2-macroglobulin-proteinase complexes protect Streptococcus pyogenes from killing by the antimicrobial peptide LL-37.
• 2003
  • Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis.
  • Elastase-producing Pseudomonas aeruginosa degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth.
  • Genome-based identification and analysis of collagen-related structural motifs in bacterial and viral proteins.
  • IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes.
  • Immunoglobulin Superantigen Protein L Induces IL-4 and IL-13 Secretion from Human Fc varepsilon RI(+) Cells Through Interaction with the kappa Light Chains of IgE.
  • Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma.
  • MtsABC Is Important for Manganese and Iron Transport, Oxidative Stress Resistance, and Virulence of Streptococcus pyogenes.
  • SIC - a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides.
  • Streptococcus pyogenes expressing M and M-like surface proteins are phagocytosed but survive inside human neutrophils.
• 2002
  • Differences in Backbone Dynamics of Two Homologous Bacterial Albumin-binding Modules: Implications for Binding Specificity and Bacterial Adaptation.
  • IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G.
  • Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coli
  • Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes.
  • Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
  • Proteolysis and its regulation at the surface of Streptococcus pyogenes.
  • Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H
  • Streptococcus pyogenes and phagocytic killing.
  • Structure, specificity, and mode of interaction for bacterial albumin-binding modules.
  • The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes.
  • Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells.
• 2001
  • Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial alpha-defensin
  • Unique regulation of SclB - a novel collagen-like surface protein of Streptococcus pyogenes
• 2000
  • SclA, a novel collagen-like surface protein of Streptococcus pyogenes
  • Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system
  • Virulent aggregates of Streptococcus pyogenes are generated by homophilic protein-protein interactions
• 1999
  • Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin
• 1998
  • Curli, fibrous surface proteins of Escherichia coli, interact with major histocompatibility complex class I molecules
  • Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes
• 1996
  • Assembly of human contact phase factors and release of bradykinin <br/>at the surface of curli-expressing Escherichia coli
  • Binding of Kininogen to the surface of Streptococcus pyogenes in plasma environment is followed by release of bradykinin.
• 1995
  • Human kininogens interact with M protein, a bacterial surface protein and virulence determinant.
  • Protein H--a bacterial surface protein with affinity for both immunoglobulin and fibronectin type III domains
  • Structure and stability of protein H and the M1 protein from Streptococcus pyogenes. Implications for other surface proteins of gram-positive bacteria
• 1994
  • Protein H--a surface protein of Streptococcus pyogenes with separate binding sites for IgG and albumin
• 1989
  • Bacterial growth inhibited by a synthetic inhibitor based upon the structure of a human proteinase inhibitor
• 1988
  • Fc epitopes for human rheumatoid factors and the relationships of rheumatoid factors to the Fc binding proteins of microorganisms
• 1984
  • On the interaction between beta 2-microglobulin and group A streptococci
• 1980
  • Effect of specific binding of human albumin, fibrinogen, and immunoglobulin G on surface characteristics of bacterial strains as revealed by partition experiments in polymer phase systems