S Albert Salehi
Titel
Forskare/Forskargruppschef
Organisation
+4640391162
S_Albert [dot] Salehi [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2012
- A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
- Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon
- Pancreatic β-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes.
- Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor beta
- Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
- Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
- Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
- Synapsin I and II Are Not Required for Insulin Secretion from Mouse Pancreatic β-cells.
- Synapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic beta-cells
- The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on beta-cells
- γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
- 2011
- Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes.
- Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.
- Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.
- Insulinotropic and Antidiabetic Effects of 17{beta}-Estradiol and the GPR30 Agonist G-1 on Human Pancreatic Islets.
- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
- 2010
- ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
- ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells.
- Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice.
- Defective secretion of islet hormones in chromogranin-B deficient mice.
- Expression of iNOS in pancreatic islets of human type 2 diabetic patients
- GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
- GPR30 New Player in Type 2 Diabetes Mellitus.
- Melatonin effects on insulin secretion and clock genes expression
- Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic beta-cells exposed to high glucose
- Mitochondrial proteome analysis reveals changes in expression of multiple proteins in pancreatic beta cells exposed to high glucose
- Novel aspects of female sex hormone estrogen in diabetes
- Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia.
- Obesity and Type 2 Diabetes: A Possible Role of GPR40.
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
- Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets.
- The role of wnt antagonists in impaired beta cell exocytosis
- α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells.
- 2009
- A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.
- Absence of adenosine A(1) receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin.
- Deletion of the G protein-coupled Receptor GPR30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-stimulated Insulin Release in Female Mice.
- Dual effects of low and high concentrations of cAMP on glucagon secretion from mouse pancreatic A-cells
- Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets.
- Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
- Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet NO generation in the mouse.
- Impaired insulin exocytosis in NCAM-/- mice due to defective reorganization of the submembrane F-actin network.
- Islet-cell secretion of pancreatic polypeptide in response to ghrelin and obestatin acting on distinct receptors
- Palmitate-stimulated hormone secretion in relation to GPR40 expression in pancreatic islets of spontaneous obesity and type 2 diabetes in rats
- Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
- The orphan receptor GPR30 and pancreatic islet hormone secretion
- 2008
- ADP mediates inhibition of insulin secretion by activation of P2Y(13) receptors
- ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors
- Adenosine A, receptors modulate glucose-induced pulses of islet hormone release
- Alpha 1 anti trypsin, modulates insulin secretion and prevents from cytokine mediated apoptosis
- CAPS1 and CAPS2 Regulate Stability and Recruitment of Insulin Granules in Mouse Pancreatic beta Cells.
- Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1
- Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.
- GLP-1 inhibits glucagon secretion by affecting several cellular mechanisms
- Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production.
- K-ATP-channels and glucagon secretion glucose-regulated
- Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon
- Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.
- Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas.
- Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities.
- Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y(6) receptors.
- 2007
- A K-ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of langerhans
- A(1) receptor deficiency causes increased insulin and glucagon secretion in mice
- GPR40 is expressed in glucagon producing cells and affects glucagon secretion.
- Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
- Insulinoscillationer--en kliniskt betydelsefull rytmik. Diabeteslakemedel bor oka den pulsatila komponenten av insulinfrisattningen
- Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
- Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon
- R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion
- Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: Evidence for the existence of insulinotropic agents in the stomach.
- 2006
- Glucose Induces Glucagon Release Pulses Antisynchronous with Insulin and Sensitive to Purinoceptor Inhibition.
- Paradoxical stimulation of glucagon secretion by high glucose concentrations
- Selective induction of inducible nitric oxide synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge.
- 2005
- Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.
- Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway
- Long-term infusion of nutrients (total parenteral nutrition) suppresses circulating ghrelin in food-deprived rats.
- 2004
- ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical actiflty by glucose in wild-type and SUR1(-/-) mouse alpha-cells
- Defective insulin secretion during total parenteral nutrition in rat and its normalization by pituitary adenylate cyclase-activating polypeptide 27.
- Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice.
- Glucose Inhibition of Glucagon Secretion From Rat alpha-Cells Is Mediated by GABA Released From Neighboring beta-Cells.
- Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase.
- 2003
- A novel mass spectrometric approach to the analysis of hormonal peptides in extracts of mouse pancreatic islets.
- Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells
- Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(V)1.2 Ca(2+) channel null mice.
- Total Parenteral Nutrition-Stimulated Activity of Inducible Nitric Oxide Synthase in Rat Pancreatic Islets is Suppressed by Glucagon-Like Peptide-1.
- 2001
- 2000
- 1999
- Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat
- Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice
- Islet constitutive nitric oxide synthase and glucose regulation of insulin release in mice
- 1998
- Biochemical and ultra-structural reactions to parenteral nutrition with two different fat emulsions in rats
- Insulin release transduction mechanism through acid glucan 1,4-alpha-glucosidase activation is Ca2+ regulated
- Signal transduction in islet hormone release: interaction of nitric oxide with basal and nutrient-induced hormone responses
- The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester potentiates insulin secretion stimulated by glucose and L-arginine independently of its action on ATP-sensitive K+ channels
- 1997
- 1996
- Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of the rat and man. A polymerase chain reaction study
- Islet acid glucan-1,4-alpha-glucosidase: a putative key enzyme in nutrient-stimulated insulin secretion
- Islet constitutive nitric oxide synthase: biochemical determination and regulatory function
- Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues
- 1995
