Anders Grubb

författare

• 2013
  • Stabilization, Characterization and Selective Removal of Cystatin C Amyloid Oligomers.
• 2012
  • Cathepsin B Degrades Amyloid-beta in Mice Expressing Wild-type Human Amyloid Precursor Protein
  • Improved estimation of glomerular filtration rate (GFR) by comparison of eGFR(cystatin C) and eGFR(creatinine)
  • Interaction of serum amyloid A with human cystatin Cuidentification of binding sites
  • Quantification of cystatin C by time-resolved fluorometry-based immunoassays
• 2011
  • Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development
  • Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation.
  • Cystatin C- and creatinine-based GFR-prediction equations for children and adults
  • High throughput testing of drug library substances and monoclonal antibodies for capacity to reduce formation of cystatin C dimers to identify candidates for treatment of hereditary cystatin C amyloid angiopathy.
  • Revised equations for estimating glomerular filtration rate based on the Lund-Malmö Study cohort.
  • The CKD-EPI and MDRD equations to estimate GFR. Validation in the Swedish Lund-Malmo Study cohort
• 2010
  • A new tool for predicting the probability of chronic kidney disease from a specific value of estimated GFR.
  • Characteristics of hCC-mAb complex
  • Crystal structure of human cystatin C stabilized against amyloid formation
  • Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice
  • Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy.
  • Dry-Reagent Double-Monoclonal Assay for Cystatin C
  • First certified reference material for cystatin C in human serum ERM-DA471/IFCC.
  • Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines
  • Non-invasive estimation of glomerular filtration rate (GFR). The Lund model: Simultaneous use of cystatin C- and creatinine-based GFR-prediction equations, clinical data and an internal quality check.
  • Performance evaluation of a turbidimetric cystatin C assay on different high-throughput platforms
  • Structure-activity relationship studies for Cystapep 1 and its analogues
• 2009
  • Different equations to combine creatinine and cystatin C to predict GFR. Arithmetic mean of existing equations performs as well as complex combinations
  • Governing the monomer-dimer ratio of human cystatin C by single amino acid substitution in the hinge region
  • Human renal function maturation: a quantitative description using weight and postmenstrual age
  • Natriuretic peptides as indicators of cardiac remodeling in hypertensive patients.
  • Serum Amyloid A Protein and C-Reactive Protein in Normal Pregnancy and Preeclampsia.
  • The Dispersion of Water Proton Spin-Lattice Relaxation Rates in Aqueous Human Protein HC (alpha(1)-Microglobulin) Solutions
  • Validation of a new plasma cystatin C-based formula and the Modification of Diet in Renal Disease creatinine-based formula for determination of glomerular filtration rate
  • Variability in diagnostic accuracy can be estimated using simple population weighting.
• 2008
  • Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease
  • Different elimination patterns of beta-trace protein, beta(2)-microglobulin and cystatin C in haemodialysis, haemodiafiltration and haemofiltration.
  • Elevated infection parameters and infection symptoms predict an acute coronary event.
  • Inaccuracy of GFR predictions by plasma cystatin C in patients without kidney dysfunction and in advanced kidney disease.
  • Increased plasma levels of ss(2)-microglobulin, cystatin C and ss-trace protein in term pregnancy are not due to utero-placental production.
  • Multicenter evaluation of a new turbidimetric Cystatin C assay for use on cobas c, Roche/Hitachi and COBAS INTEGRA (R) systems
  • Standardization of Cystatin C: development of primary and secondary reference preparations.
  • The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children
  • The impact of human cystatin C hinge loop L1 on its dimerization and oligomerization propensity
• 2007
  • Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
  • Cystatin C reduces the in vitro formation of soluble A beta 1-42 oligomers and protofibrils
  • Cystatin C, beta-2-microglobulin and beta-trace protein in pre-eclampsia
  • Fibrillogenic oligomers of human cystatin C are formed by propagated domain swapping.
  • Prediction of relative glomerular filtration rate in adults: New improved equations based on Swedish Caucasians and standardized plasma-creatinine assays.
  • SAXS studies of human protein HC (alpha(1)-microglobulin)
  • Temporal changes of the plasma levels of cystatin C, beta-trace protein, beta(2)-microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process
• 2006
  • Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
  • Checking the conformational stability of cystatin C and its L68Q variant by molecular dynamics studies: Why is the L68Q variant amyloidogenic?
  • Errors in the assessment of estimated glomerular filtration rate: reply.
  • Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes.
  • Glycemic and non-glycemic effects of pioglitazone in triple oral therapy in patients with type 2 diabetes mellitus
  • Lowered levels of serum albumin and HDL-cholesterol in children with a recent mild infection.
  • Notable steps in obtaining improved estimates for glomerular filtration rate
  • Search of synthetic low-molecular peptide derivatives with activity against fungal pathogens
  • Standardization of p-creatinine assays and use of lean body mass allow improved prediction of calculated glomerular filtration rate in adults: A new equation
  • The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models
• 2005
  • 3D domain-swapped human cystatin c with amyloidlike intermolecular beta-sheets
  • A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula.
  • Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.
  • Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E-Null Mice.
  • Cystatin C as a marker of GFR - history, indications, and future research
  • Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
  • Different cysteine proteinases involved in bone resorption and osteoclast formation
  • In search of selective inhibitors of cysteine protease, cathepsin K
  • Lack of the Cysteine-Protease Inhibitor Cystatin C Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.
  • Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
  • Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
  • Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children.
• 2004
  • Author's Reply.
  • Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L
  • Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells.
  • Cysteine proteinases in osteoclast function and recruitment
  • Domain swapping in N-truncated human cystatin C
  • Effect of antisense peptide binding on the dimerization of human cystatin C - gel electrophoresis and molecular modeling studies
  • Elevated Plasma Levels of Nt-proBNP in Patients With Type 2 Diabetes Without Overt Cardiovascular Disease.
  • Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants
  • Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.
  • New antimicrobial peptide active against Gram-positive pathogens
  • New antimicrobial peptide active against Gram-positive pathogens.
  • Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.
  • Osteoclastogenesis is decreased by cysteine proteinase inhibitors
  • Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C. Use of engineered disulfide bridges, antibodies and carboxymethylpapain to stabilize the monomeric form of cystatin C.
  • Serum cystatin C advantageous compared with serum creatinine in the detection of mild but not severe diabetic nephropathy.
• 2003
  • C-reactive protein levels following standard neurosurgical procedures
  • Factors influencing analysis of prolyl endopeptidase in human blood and cerebrospinal fluid: increase in assay sensitivity.
  • Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys
  • New antimicrobial cystatin C-based peptide active against gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus and multiresistant coagulase-negative staphylococci.
  • Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine in renal transplantation.
  • Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre-eclamptic pregnancies.
  • The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation
• 2002
  • Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases
  • Development of monoclonal antibodies against creatine kinase MB2
  • Serum cystatin C for assessment of glomerular filtration rate in pregnant and non-pregnant women. Indications of altered filtration process in pregnancy.
• 2001
  • Comparative study of Helicobacter pylori infection in guinea pigs and mice - elevation of acute-phase protein C3 in infected guinea pigs
  • Cystatin C inhibits osteoclast formation and activation via different mechanisms
  • Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping
  • Peptidyl diazomethylketones as cysteine protease inhibitors structurally based upon the inhibitory centers of cystatins
  • Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate
  • Structural studies of cysteine proteases and their inhibitors
  • Urine excretion of protein HC in proteinuric glomerular diseases correlates to urine IgG but not to albuminuria
• 2000
  • A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro
• 1999
  • Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene
  • Expression of a selenomethionine derivative and preliminary crystallographic studies of human cystatin C
  • Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults
• 1998
  • Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor
  • Structural basis for different inhibitory specificities of human cystatins C and D
• 1997
  • Albumin adducts in plasma from workers exposed to toluene diisocyanate
  • Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia
  • Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
• 1996
  • Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution
• 1995
  • Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases
• 1994
  • Increased body temperature accelerates aggregation of the (Leu-68–>Gln) mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy
  • Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate
• 1993
  • A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level
  • An Ala/Thr variation in the coding region of the human cystatin C gene (CST3) detected as a Sst II polymorphism
  • Human cystatin D: cDNA cloning, characterization of the E. coli expressed inhibitor, and identification of the native protein in saliva
  • Importance of the evolutionarily conserved glycine residue in the N-terminal region of cystatin C (Gly-11) for cysteine endopeptidase inhibition
• 1992
  • A novel mutation in the β-protein coding region of the amyloid β-protein precursor (APP) gene
  • Cystatin C based peptidyl diazomethanes as cysteine proteinase inhibitors: Influence of the peptidyl chain length
  • Demonstration of sequence variations in the promoter region of the human cystatin C gene
  • Hereditary cystatin C amyloid angiopathy: Identification of the disease causing mutation and specific diagnosis by polymerase chain reaction based analysis
• 1991
  • Determination of allotypes G1m(f) and G1m(z) at the genomic level by subclass specific amplification of DNA and use of allele specific probes
  • Human cystatin C: Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase
  • Protein D, an immunoglobulin D-binding protein of Haemophilus influenzae: cloning, nucleotide sequence, and expression in Escherichia coli
  • Regulation of cystatin C activity by serine proteinases
  • Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor
• 1990
  • Assignment of allotypes G1m(a+) and G1m(a-) at the genomic level by polymerase chain reaction analysis
  • Cystatin C mutation causing amyloid angiopathy and brain hemorrhage
  • Structure and expression of the human cystatin C gene
  • Synthesis of cysteine proteinase inhibitors structurally based on the proteinase interacting N-terminal region of human cystatin C
  • The aminoterminal portion of cerebrospinal fluid cystatin C in hereditary cystatin C amyloid angiopathy is not truncated. Direct sequence analysis from agarose gel electropherograms
  • Three RFLP's at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland
• 1989
  • An efficient E. coli expression system for human cystatin C: Production and characterization of the native and N-terminally Ala-Met-Glu-Ala-Glu-extended inhibitor
  • Bacterial growth inhibited by a synthetic inhibitor based upon the structure of a human proteinase inhibitor
  • High-level expression of active human cystatin C in Escherichia coli
  • Mutation in the cystatin C gene causes hereditary brain hemorrhage
  • Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients
• 1988
  • An isolate of families with hereditary cystatin C amyloid angiopathy and cerebral haemorrhage in the south of Iceland
  • Efficient production of native, biologically active human cystatin C by Escherichia coli
  • Mutation in cystatin C gene causes hereditary brain haemorrhage
  • Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitors cystatin C and kininogen
  • Studies on the cystatin C gene in patients with hereditary cystatin C amyloid angiopathy (HCCAA) with cerebral haemorrhage
• 1987
  • Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin
  • Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C
• 1986
  • Cystatin-like domains of LMW-kininogen, and speculations on the evolution of cystatins
  • Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases.
  • Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids
• 1984
  • Human immunoglobulin class and subclass specificity of Fc receptors induced by herpes simplex virus type 1