Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Genetic association analysis of LARS2 with type 2 diabetes

In English

Författare

  • E. Reiling
  • B. Jafar-Mohammadi
  • E. van't Riet
  • M. N. Weedon
  • J. V. van Vliet-Ostaptchouk
  • T. Hansen
  • R. Saxena
  • T. W. van Haeften
  • P. A. Arp
  • S. Das
  • G. Nijpels
  • M. J. Groenewoud
  • E. C. van Hove
  • A. G. Uitterlinden
  • J. W. A. Smit
  • A. D. Morris
  • A. S. F. Doney
  • C. N. A. Palmer
  • C. Guiducci
  • A. T. Hattersley
  • T. M. Frayling
  • O. Pedersen
  • P. E. Slagboom
  • D. M. Altshuler
  • Leif Groop
  • J. A. Romijn
  • J. A. Maassen
  • M. H. Hofker
  • J. M. Dekker
  • M. I. McCarthy
  • L. M. 't Hart
Visa allt

Summary, in English

LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide levels of significance. The aim of this study was to establish the true contribution of this variant and common variants in LARS2 (MAF > 5%) to type 2 diabetes risk. We combined genome-wide association data (n = 10,128) from the DIAGRAM consortium with independent data derived from a tagging single nucleotide polymorphism (SNP) approach in Dutch individuals (n = 999) and took forward two SNPs of interest to replication in up to 11,163 Dutch participants (rs17637703 and rs952621). In addition, because inspection of genome-wide association study data identified a cluster of low-frequency variants with evidence of type 2 diabetes association, we attempted replication of rs9825041 (a proxy for this group) and the previously identified H324Q variant in up to 35,715 participants of European descent. No association between the common SNPs in LARS2 and type 2 diabetes was found. Our replication studies for the two low-frequency variants, rs9825041 and H324Q, failed to confirm an association with type 2 diabetes in Dutch, Scandinavian and UK samples (OR 1.03 [95% CI 0.95-1.12], p = 0.45, n = 31,962 and OR 0.99 [0.90-1.08], p = 0.78, n = 35,715 respectively). In this study, the largest study examining the role of sequence variants in LARS2 in type 2 diabetes susceptibility, we found no evidence to support previous data indicating a role in type 2 diabetes susceptibility.

Publiceringsår

2010

Språk

Engelska

Sidor

103-110

Publikation/Tidskrift/Serie

Diabetologia

Volym

53

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Endocrinology and Diabetes

Nyckelord

  • Type 2 diabetes
  • SNP
  • Mitochondria
  • Genetics
  • LARS2

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISSN: 1432-0428