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Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C

In English

Författare

Summary, in English

Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189.

Publiceringsår

2012

Språk

Engelska

Sidor

1183-1189

Publikation/Tidskrift/Serie

Journal of Lipid Research

Volym

53

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Biochemistry and Molecular Biology

Ämne

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics

Nyckelord

  • diet
  • fatty acid desaturase
  • polyunsaturated fatty acids
  • cholesterol
  • cohort
  • epidemiology
  • low density lipoprotein cholesterol

Status

Published

Projekt

  • Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

Forskningsgrupp

  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 1539-7262