Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1
Författare
Summary, in English
Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
116-124
Publikation/Tidskrift/Serie
Journal of Immunological Methods
Volym
316
Issue
1-2
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Immunology in the medical area
Nyckelord
- tumour-associated antigen
- specificity
- peptide
- antigen
- antibody
- antibody library
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1872-7905