Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Down-modulation of the antigen receptor by a superantigen for human B cells

In English

Författare

Summary, in English

B cell superantigens (SAgs) have been implicated in human diseases by demonstrating non-clonotypic expansion of B cells bearing certain immunoglobulin variable region genes. One possibility is that, during infection with microorganisms secreting SAgs, these potent molecules might modulate BcR expression. To test this hypothesis, we investigated the potential effects of a SAg, protein L from Peptostreptococcus magnus, on antigen B cell receptor (BcR) surface expression in vitro. Using fluorescence microscopy, we found that this SAg induced down-regulation of BcR expression. This effect was time-, dose-, and temperature-dependent, and shedding of cell surface IgM molecules into the culture supernatant was not detected. These data demonstrate that SAg-mediated down-regulation of the BcR expression occurs primarily as a result of BcR internalization. In addition, two specific inhibitors of protein tyrosine kinases were found to retard the BcR modulation on the cell surface and inhibit SAg-induced receptor internalization, showing that tyrosine phosphorylation is required for subsequent internalization of mIg-ligand complexes. The down-modulation of BcR expression may have pathological consequences in patients infected with microorganisms secreting SAgs. (C) 2003 Elsevier B.V. All rights reserved.

Avdelning/ar

Publiceringsår

2004

Språk

Engelska

Sidor

91-96

Publikation/Tidskrift/Serie

Immunology Letters

Volym

92

Issue

1-2

Dokumenttyp

Konferensbidrag

Förlag

Elsevier

Ämne

  • Infectious Medicine

Nyckelord

  • B cell receptor
  • receptor internalization
  • protein L

Conference name

12th Symposium on Signals and Signal Processing in the Immune System

Conference date

2003-09-03 - 2003-09-07

Conference place

Sopron, Hungary

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0165-2478
  • ISSN: 1879-0542