A von Willebrand factor-binding protein from Staphylococcus lugdunensis
Författare
Summary, in English
In the present study, a phage display library covering the genome of Staphylococcus lugdunensis, was affinity-selected against von Willebrand factor (vWf). This led to the identification of a gene, vwbl, encoding a Putative cell surface protein of 2060 amino acids, denoted vWbl. The deduced protein has an overall organisation typical of staphylococcal cell Surface proteins, with an N-terminal signal peptide, and a C-terminal cell wall sorting signal. The vWf-binding part is located in repetitive domains and antibodies against vWbl or vWf can inhibit the binding. Southern blot analysis showed that vwbl was present in the 12 S. lugdunensis strains tested. (C) 2004 Federation of European Microbiological Societies.
Avdelning/ar
Publiceringsår
2004
Språk
Engelska
Sidor
155-161
Publikation/Tidskrift/Serie
FEMS Microbiology Letters
Volym
234
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Microbiology in the medical area
Nyckelord
- von Willebrand factor
- display
- phage
- coagulase-negative staphylococci
- Staphylococcus lugdunensis
- adhesin
- LPXTG motif
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1574-6968