L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment.
Författare
Summary, in English
L-DOPA-induced dyskinesia (LID) is a common complication of the treatment of Parkinson's disease, and its precise mechanisms have long remained unknown. Rodent models of LID provide a tool to dissect the impact of specific factors on the development and expression of dyskinetic movements. This short review will summarize recent findings from rodent studies that have consolidated and considerably expanded our mechanistic understanding of LID. Based on the experimental findings, the review will propose a chart of possible treatment options acting on different pathophysiological levels.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
263-267
Publikation/Tidskrift/Serie
Parkinsonism & Related Disorders
Volym
13 Suppl 3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Neurology
Status
Published
Forskningsgrupp
- Basal Ganglia Pathophysiology
ISBN/ISSN/Övrigt
- ISSN: 1873-5126