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Immunocytochemical localization of galanin in the rat male and female genital tracts and motor effects in vitro

In English

Författare

Summary, in English

Galanin, a recently discovered neuropeptide, was studied in the rat male and female reproductive tracts by immunocytochemistry and in vitro pharmacology. Nerve fibers containing galanin immunoreactivity were most abundant in the female paracervical tissue, where they surrounded non-immunoreactive ganglion cells. Galanin nerves were also found in the uterus and Fallopian tubes, as well as in the vas deferens. When tested in vitro galanin contracted the smooth muscle of both the uterine horn and cervix. Galanin also slightly potentiated the response to electrical field stimulation in preparations from the uterine cervix and vas deferens, but it had no effect on the seminal vesicle. Galanin-(1-10), an N-terminal residue of galanin, also contracted the uterine horn, though higher concentrations were required. The neurally induced contractions were not influenced by galanin-(1-10) in any of the smooth muscle preparations tested. The muscle receptors mediating the direct contractile effects in the uterine horn seem to require the N-terminus of galanin, while the neuromodulatory effects on the electrically induced contractile activity seem to need the C-terminal part or the whole galanin molecule. Galanin may thus function as a neuromediator in the rat male and female genital organs.

Avdelning/ar

Publiceringsår

1988

Språk

Engelska

Sidor

335-343

Publikation/Tidskrift/Serie

Regulatory Peptides

Volym

20

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Cell and Molecular Biology

Nyckelord

  • Galanin
  • Neuropeptide
  • Male and female genital tracts
  • Uterus
  • Vas deferens
  • Seminal vesicle
  • Smooth muscle
  • Immunocytochemistry
  • In vitro pharmacology

Status

Published

Forskningsgrupp

  • Urogynaecology and Reproductive Pharmacology
  • Neurogastroenterology
  • Drug Target Discovery

ISBN/ISSN/Övrigt

  • ISSN: 1873-1686