TGF-β signaling in the control of hematopoietic stem cells.

Summary, in English

Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated process that requires constant replenishment. All mature blood cells are generated from hematopoietic stem cells (HSCs), which are the self-renewing units that sustain life-long hematopoiesis. HSC behavior, such as self-renewal and quiescence, are regulated by a wide array of factors, including external signaling cues present in the bone marrow. The Transforming Growth Factor-β (TGF-β) family of cytokines constitutes a multifunctional signaling circuitry, which regulates pivotal functions related to cell fate and behavior in virtually all tissues of the body. In the hematopoietic system, TGF-β signaling controls a wide spectrum of biological processes, from homeostasis of the immune system to quiescence and self-renewal of HSCs. Here, we review key features and emerging concepts pertaining to TGF-β and downstream signaling pathways in normal HSC biology, featuring aspects of aging, hematological disease, and how this circuitry may be exploited for clinical purposes in the future.

• Författare: Ulrika Blank Savukinas; Stefan Karlsson
• Avdelning/ar: Avdelningen för molekylärmedicin och genterapi; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 3542-3550
• Publikation/Tidskrift/Serie: Blood
• Volym: 125
• Issue: 23
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25833962?dopt=Abstract; http://dx.doi.org/10.1182/blood-2014-12-618090
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society of Hematology
• Ämne: Hematology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1528-0020