Bioactive alkenylphenols from Piper obliquum.

Summary, in English

Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

• Författare: Carola Valdivia; Nieves Marquez; John Eriksson; Antonio Vilaseca; Eduardo Muñoz; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes; Teknisk mikrobiologi
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 4120-4126
• Publikation/Tidskrift/Serie: Bioorganic & Medicinal Chemistry
• Volym: 16
• Issue: 7
• Länkar: http://dx.doi.org/10.1016/j.bmc.2008.01.018
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Organic Chemistry; Industrial Biotechnology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0968-0896