HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

Summary, in English

Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.

• Författare: Camilla Thuring; Elna Follin; Linda Geironson Ulfsson; Eva Freyhult; Victoria Junghans; Mikkel Harndahl; Søren Buus; Kajsa M Paulsson
• Avdelning/ar: Antigen presentation; Avdelningen för molekylär hematologi; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 952-962
• Publikation/Tidskrift/Serie: British Journal of Cancer
• Volym: 113
• Issue: 6
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26313662?dopt=Abstract; http://dx.doi.org/10.1038/bjc.2015.297
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Cancer and Oncology
• Nyckelord: HLA-I; tapasin; glioblastoma multiforme; peptide; tapasin-dependency; immunotherapy
• Status: Published
• Forskningsgrupp: Antigen Presentation
• ISBN/ISSN/Övrigt: ISSN: 1532-1827