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Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21-q29 in head and neck carcinomas.

In English

Författare

Summary, in English

Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH and FISH with specific probes to identify and characterize chromosomal segments added to the derivative chromosomes 11. In 4 of the tumors, it could be recognized that the material added was derived from the long arm of chromosome 3. The rearrangements were interpreted as der(11)hsr(11)(q13)t(3;11)(q21;q13) in 3 cases and as der(11)hsr(11)(q13)t(3;11)(q14;q13) in 1 case. In the other 4 cases, material from chromosomes 1, 16, or 19 was added to the derivative chromosomes 11. By further FISH analysis with 14 YAC clones spanning 3q13-q21 in the 4 tumors with der(11)hsr(11)t(3;11), it could be shown that they had different breakpoints at the molecular level, excluding the possibility that a particular gene was rearranged by the translocations. More surprisingly, gain of the 3q21-q29 segment was found in all 8 tumors with hsr in 11q13 and loss of 3p was seen in 7 of the tumors. These findings strongly indicate a synergistic effect of CCND1 amplification, loss of distal 11q, 3q gain and 3p deletion in HNSCC development and also suggests a mechanistic link between intrachromosomal amplification at 11q13 and recombination with distal 3q.

Publiceringsår

2002

Språk

Engelska

Sidor

475-479

Publikation/Tidskrift/Serie

International Journal of Cancer

Volym

98

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Cancer and Oncology

Nyckelord

  • Head and Neck Neoplasms : metabolism
  • Male
  • Human
  • In Situ Hybridization
  • Fluorescence
  • Middle Age
  • Head and Neck Neoplasms : genetics
  • Gene Amplification
  • Female
  • Neoplasm : metabolism
  • DNA
  • Cyclin D1 : metabolism
  • Cyclin D1 : genetics
  • Pair 3 : genetics
  • Chromosomes
  • Pair 11 : genetics
  • Squamous Cell : metabolism
  • Carcinoma
  • Squamous Cell : genetics
  • Aged
  • Biopsy
  • Support
  • Non-U.S. Gov't

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0020-7136