Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis
Författare
Summary, in English
Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.
Avdelning/ar
Publiceringsår
2016-03-21
Språk
Engelska
Publikation/Tidskrift/Serie
Experimental Dermatology
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Dermatology and Venereal Diseases
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0906-6705